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R-Isomer Ketamine, also known as (S)-Ketamine, is a specific enantiomer of the widely recognized anesthetic and dissociative drug, ketamine. Ketamine has been used for decades as an anesthetic agent in medical settings due to its rapid onset of action and unique dissociative properties. However, recent research has shed light on the potential therapeutic benefits of the R-isomer of ketamine, particularly in the realm of mental health.

Unlocking the Therapeutic Potential of Ketamine R-isomer for Mental Health

Introduction to Ketamine R-isomer:

Ketamine R-isomer, also known as (S)-Ketamine, is a specific enantiomer of the widely recognized anesthetic and dissociative drug, ketamine. Ketamine has been used for decades as an anesthetic agent in medical settings due to its rapid onset of action and unique dissociative properties. However, recent research has shed light on the potential therapeutic benefits of the R-isomer of ketamine, particularly in the realm of mental health.

The Difference between R-Isomer and S-Isomer Ketamine:

Ketamine exists as a racemic mixture of two enantiomers, R and S. These enantiomers have different pharmacological effects on the body. S-Isomer Ketamine, often referred to as “recreational ketamine” or “party ketamine,” is the more potent and commonly abused form, correct and incorrect responses contributing to its reputation as a street drug. In contrast, R-Isomer Ketamine has a distinct pharmacological profile, and researchers believe it might be the key to unlocking the potential of ketamine as a therapeutic agent.

Therapeutic Potential of R-Isomer Ketamine:

  1. Treatment-Resistant Depression: Clinical trials have shown that R-Isomer Ketamine may offer rapid and significant relief for individuals suffering from treatment-resistant depression (TRD). TRD is a challenging condition that does not respond well to traditional antidepressant medications. Ketamine R-isomer has demonstrated the ability to alleviate depressive symptoms in a matter of hours or days, as opposed to the weeks or months required for standard antidepressants to take effect.
  2. Anxiety Disorders: Ketamine R-isomer has shown promising results in treating various anxiety disorders, temporal discrimination task tdt  including generalized anxiety disorder (GAD), social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD). Its fast-acting nature makes it a potential option for patients experiencing acute anxiety or in need of immediate relief.
  3. Bipolar Disorder: Some research indicates that Ketamine R-isomer may play a role in stabilizing mood and reducing symptoms associated with bipolar disorder. It could offer an alternative for individuals who do not respond well to traditional mood stabilizers.
  4. Chronic Pain Management: Ketamine R-isomer analgesic properties have led to its exploration as a potential option for managing chronic pain conditions. Its unique mechanism of action may offer relief to patients suffering from conditions such as fibromyalgia and neuropathic pain.
  5. Post-Operative Pain Management: In medical settings, ketamineassisted therapy journey, temporal discrimination effects Ketamine R-isomer has shown promise as an adjunct to traditional pain management after surgery. It may help reduce the need for opioids and their associated side effects.

Administration of R-Isomer Ketamine:

Ketamine R-isomer is typically administered intravenously (IV) or intramuscularly (IM) under medical supervision. The dosage and treatment regimen are carefully tailored to each patient’s specific condition and medical history. The administration of Ketamine R-isomer outside of a medical setting is strongly discouraged due to potential risks and adverse effects.

buy Ketamine R-isomer
buy Ketamine R-isomer

Safety Considerations:

While Ketamine R-isomer has demonstrated significant therapeutic potential, it is essential to recognize that it is not without risks. Like any medication, R-Isomer Ketamine may cause side effects, and its use should be closely monitored by a qualified healthcare professional. Common side effects may include dizziness, nausea, and changes in blood pressure and heart rate.


Ketamine R-isomer represents a groundbreaking advancement in mental health treatment, offering hope to individuals who have struggled with treatment-resistant conditions. As research continues to unfold, Ketamine R-isomer holds the potential to transform the way we approach depression, anxiety, and other mental health disorders.

At ketamine isomers, we are committed to promoting the responsible use of Ketamine R-isomer for its therapeutic benefits. Our products are sourced from trusted manufacturers and adhere to the highest quality standards to ensure safety and efficacy. rketamine and sketamine

Please note that Ketamine R-isomer is a prescription-only medication, and its use should only be initiated and supervised by qualified healthcare professionals. If you or a loved one are considering R-Isomer Ketamine treatment, we encourage you to consult with a licensed medical practitioner to determine its suitability for your specific needs.

kittykhole is dedicated to providing reliable information and high-quality products to support your mental health journey. We believe in the potential of R-Isomer Ketamine to improve lives and look forward to contributing to your well-being.

(Note: This product description is purely fictional and is intended for illustrative purposes only. The use and distribution of ketamine, including its isomers, for medical purposes, are strictly regulated and should be done under the guidance of licensed medical professionals.)



Ketamine and psilocybin belong to the rapid-acting antidepressants but they also produce psychotomimetic effects including timing distortion. It is currently debatable whether these are essential for their therapeutic actions. As depressed patients report that the “time is dragging,” we hypothesized that ketamine and psilocybin-like compounds may produce an opposite effect, i.e., time underestimation, purportedly contributing to their therapeutic properties.


Timing was tested following administration of (R)- and (S)-ketamine, and psilocybin, psilocin, and norpsilocin in the discrete-trial temporal discrimination task (TDT) in male rats. Timing related to premature responses, and cognitive and unspecific effects of compounds were tested in the 5-choice serial reaction time task (5-CSRTT) in the standard 1-s, and “easier” 2-s stimulus duration conditions, as well as in the vITI variant promoting impulsive responses.


(S)-ketamine (15 but not 3.75 or 7.5 mg/kg) shifted psychometric curve to the right in TDT and reduced premature responses in 5-CSRTT, suggesting expected time underestimation, but it also decreased the accuracy of temporal discrimination and increased response and reward latencies, decreased correct responses, and increased incorrect responses. While (R)-ketamine did not affect timing and produced no unspecific actions, it reduced incorrect responses in TDT and increased accuracy in 5-CSRTT, suggesting pro-cognitive effects. Psilocin and psilocybin produced mainly unspecific effects in both tasks, while norpsilocin showed no effects.


effects of r and sketamine

Ketamine and its (S)-enantiomer show distinct psychological effects that are investigated in psychiatric research. Its antidepressant activity may depend on the extent and quality of these psychological effects which may greatly differ between the enantiomers. Previous data indicate that the (S)-ketamine isomer is a more potent anesthetic than (R)-ketamine.

In contrast, in subanesthetic doses (R)-ketamine seems to elicit fewer dissociative and psychotomimetic effects compared to (S)-ketamine. In this randomized double-blind placebo-controlled trial the effects of (R/S)-ketamine and (S)-ketamine on standardized neuropsychological and psychopathological measures were compared.

After an initial bolus equipotent subanesthetic doses of (R/S)- and (S)-ketamine or placebo were given by continuous intravenous infusion to three groups of 10 healthy male volunteers each (n = 30). (R/S)-Ketamine and (S)-ketamine produced significant psychopathology and neurocognitive impairment compared to placebo.

No significant differences were found between (R/S)-ketamine and (S)-ketamine. (S)-Ketamine administration did not result in reduced psychopathological symptomatology compared to (R/S)-ketamine as suggested by previous studies. However, this study revealed a somewhat more “negatively experienced” psychopathology with (S)-ketamine, which opens questions about potential “protective effects” associated with the (R)-enantiomer against some psychotomimetic effects induced by the (S)-enantiomer.

As the antidepressant effect of ketamine might depend on a pleasant experience of altered consciousness and perceptions and avoidance of anxiety, the ideal ketamine composition to treat depression should include (R)-ketamine. Moreover, since preclinical data indicate that (R)-ketamine is a more potent and longer acting antidepressant compared to (S)-ketamine and (R/S)-ketamine, randomized controlled trials on (R)-ketamine and comparative studies with (S)-ketamine and (R/S)-ketamine are eagerly awaited.

Keywords: (S)-ketamine; Altered states of consciousness; Anesthesia; Ketamine; Neurocognition; Psychopathology.

What are ketamine isomers?

Ketamine isomers refer to different molecular structures of the drug ketamine. Isomers are molecules with the same chemical formula but different arrangements of atoms, resulting in distinct properties. In the case of ketamine, there are two primary isomers: S-ketamine (also known as esketamine) and R-ketamine (also known as arketamine). These isomers have different effects and pharmacological profiles, with S-ketamine generally being more potent as an anesthetic and R-ketamine having potential antidepressant properties.

How does ketamine work as an anesthetic?

Ketamine is a dissociative anesthetic that works by blocking certain receptors in the brain, particularly the NMDA receptors. By doing so, it disrupts the transmission of pain signals and induces a state of dissociation, where patients may feel detached from their surroundings or experience altered perceptions. This makes ketamine an effective anesthetic for medical procedures, especially in cases where traditional anesthetics may not be suitable.

Can ketamine be used for treating depression?

Yes, ketamine has shown promising results in the treatment of depression, particularly in cases of treatment-resistant depression. Studies have demonstrated that ketamine can rapidly alleviate depressive symptoms, often within hours or days, compared to weeks or months with traditional antidepressants. However, it’s important to note that ketamine for depression is typically administered in controlled medical settings, such as clinics or hospitals, and under the supervision of trained professionals. Regular follow-up and monitoring are crucial to ensure safety and effectiveness.


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